As of my last knowledge update in January 2022, here are some of the largest cities in Guatemala, ranked by population. Please note that population figures may have changed since then.

20 Biggest cities in Guatemala

1. Guatemala City (Ciudad de Guatemala)
2. Mixco
3. Villa Nueva
4. Quetzaltenango
5. San Miguel Petapa
6. Escuintla
7. San Juan Sacatepéquez
8. Villa Canales
9. Chinautla
10. Chimaltenango
11. Amatitlán
12. Totonicapán
13. Huehuetenango
14. Quetzaltepeque
15. Mazatenango
16. Cobán
17. Chichicastenango
18. Puerto Barrios
19. La Gomera
20. Jalapa

Keep in mind that population figures can change over time, and it’s advisable to refer to the latest demographic data for the most accurate information.

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